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Side effects like nausea, vomiting, and diarrhea are very common during the titration phase

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Usually, yes

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Glioma-targeted dual functionalized thermosensitive Ferri-liposomes for drug delivery through an in vitro bloodbrain barrier

GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinsons disease in transgenic Parkin Q311X(A) mice