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The medication helps the pancreas release insulin when blood glucose levels rise, reduces the amount of sugar released by the liver, and slows down how quickly food leaves the stomach, though some patients may experience constipation or, in rare cases, pancreatitis

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Beyond GI effects, patients frequently ask about muscle loss

Timelines vary

Gradual titration: prescribers usually start low to improve stomach-related tolerability

Pragmatism The Pharmacokinetic Argument (FDA/ADA): The FDAs 34 day rule is derived from the half-life of SGLT2 inhibitors (typically 1113 hours for dapagliflozin/empagliflozin) (36)