More often, its downstream of something else: Hormonal changes perimenopause, postpartum recovery, low testosterone, estrogen dominance Thyroid dysfunction (which is why we run four thyroid markers, not one) Insulin resistance and elevated fasting insulin, often years before blood sugar shows up as abnormal Chronic inflammation, gut issues, or nutrient deficiencies (vitamin D and B12 are common offenders) Cortisol and sleep disruption a real factor for new moms, shift workers, and high-stress professionals A GLP-1 wont fix any of those
Although trial data is limited, some GLP1s have been used off-label in dialysis patients with close monitoring
Keep the vial upright, away from light, and discard any solution that becomes cloudy, discolored, or develops particles
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Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote
