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This is perhaps a little surprising, since IGF-1 is a growth promoting substance, hence we would expect that it could promote growth for every type of cancer

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These metabolic pathways not only drive the progression of each disease independently but are also interconnected through shared biological mechanisms

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They include various free radicals and reactive molecules formed from molecular oxygen and nitrogen, including superoxide anion radical (O ), hydroxyl radical (OH ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO ) [28]