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Ask yourself, "What would I tell a friend in this situation?" or "Is this thought based on fact or a feeling?" Replace a negative thought with a positive one, like "I am a good person who is working to be healthier," or "I am grateful for my body's strength." Challenge negative self-talk

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10.1016/j.jacbts.2021.04.006 178 ShirakawaJ.FujiiH.OhnumaK.SatoK.ItoY.KajiM.et al (2011)

Like CaMKK2, the PKA signalling pathway is also considered to play a key role in the pathogenesis of bipolar disorder, as increased cyclic AMP levels and PKA activity have been frequently observed in post-mortem brains and peripheral cells of bipolar disorder patients [58,59,60,61]