CoQ10 might lower blood pressure, and usually, you could count this effect as a benefit
Atakisi E, Topcu B, Yildiz Dalginli K, et al (2016) Acute effects of N-acetylcysteine on total antioxidant capacity, total oxidant capacity, nitric oxide level and gammaglutamyl transpeptidase activity in rabbits
Bibi et al., 2025)
It has the advantages of being easy to use, non-invasive, and lower in cost than polysomnography, but does not directly measure sleep, and does not include data regarding sleep architecture or breathing abnormalities
doi: 10.1021/acsnano.3c02646 121 PintoS.ajbenovD.BenincE.NooijS.TerveerE
Hence, each microstate will contain all possible ligand, protein and solvent arrangements compatible with having the ligands center of mass within the cell