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Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Quantifying CagriSemas action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake

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I imagine weight loss and A1C outcomes will be similar but the extra metabolic benefits may be the key

Ethical approval All experimental procedures were carried out according to Polish Ethical Standards and approved by the First Local Ethical Committee in Krakow, Poland (approval no 451/2020, 25th November 2020