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These effects typically relate to reduced food intake and caloric adaptation

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For instance, HDAC1, HDAC2, and HDAC3, which belong to class I HDACs, have been demonstrated to mediate the deacetylation of mitogen-activated protein (MAP) kinase phosphatase 1 (MKP1), resulting in elevation of MAP kinase (MAPK) and suppression of innate immune signaling [62]

This imbalance compromises cellular equilibrium and initiates inflammation, which is necessary for immune defense

Costa, C