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If you develop symptoms of diabetic ketoacidosis (nausea, vomiting, abdominal pain, fruity-smelling breath), this is a medical emergencycall 999 or go to A&E immediately

Practice strategy: Convert 32% of the medical loss patients to primary care long term patients, using PLATINUM service

Semaglutide 2.4 mg weekly, assessed in 17,604 individuals with body mass index (BMI) 27 kg/m and cardiovascular disease (CVD), resulted in 8.51% weight loss at 104 weeks and a 20% reduction in nonfatal Myocardial Infarction (MI), stroke, and cardiovascular death

It was first approved for the treatment of type 2 diabetes as a once-weekly injection (0.5 mg, 1 mg, or 2 mg) in 2017 (Ozempic) and as a once-daily oral pill (7 mg or 14 mg) in 2019 (Rybelsus)

Treated mice displayed myofibers nearly twice as large in cross-sectional area and demonstrated higher contractile strength, with reports of up to 70% greater force compared to untreated groups

The STEP 1 trial extension found that participants who stopped semaglutide regained around two-thirds of their lost weight within a year