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Therapeutic approaches Limiting TMA precursors in individuals with elevated TMAO would be prudent

24 Furthermore, the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease trial, which involved participants with stage 2 to 4 CKD and moderately elevated albuminuria or stage 1 or 2 CKD and severely increased albuminuria, showed a reduction in CV morbidity, most prominently through a reduction in heart failure-related hospitalisations, with finerenone therapy

Acknowledgements The authors wish to thank Dr Nasrin Shokrpour at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for her invaluable assistance in editing this manuscript