glp-1 and serotonin Anti-Obesity Rx Alcohol and Substance Use Disorders Frontiers | Pleiotropic Effects of

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Most studies look at each medication individually

Tirzepatide (Mounjaro, Zepbound) Strengths: Highest efficacy for both glucose control and weight loss Dual mechanism (GLP-1 + GIP) may provide unique benefits Once-weekly dosing Generally well-tolerated Considerations: Higher cost than semaglutide Less long-term safety data (newer medication) Cardiovascular outcome trial not yet complete (though expected to be positive) Best for: Patients prioritizing maximum weight loss

space consumption by at least 24 hours when possible

With proper medical guidance, semaglutide can support not only weight loss but also improved overall health, including healthier, more restful sleep

8 , eabm4389 (2022)