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Injection site monitoring prevents local complications

The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year

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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop

SB-01 is a synthetic 7-amino-acid peptide in clinical trials that downregulates TGF-beta-1, a growth factor highly expressed in degenerated discs