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Furthermore, the expression of antibiotic class-specific influx channels and their functional overlap, and the fact that many metabolites impact several metabolic pathways, complicate the design of effective interventions targeting membrane permeability

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Inhibition of ASCT2-mediated GLN uptake in human cells using a lead compound (V-9302) resulted in attenuation of cancer cell growth and proliferation, frequent cell death, and increased oxidative stress [28]