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The SMR analysis showed that each standard deviation increase in GLP1R gene expression (the target of the GLP-1 receptor, probe: ENSG00000112164) was associated with a reduced risk of anxiety (OR:0.79, 95% CI:0.640.98, P = 0.031) (Figure 9)

Inagawa R, Okada H, Takemura G, Suzuki K, Takada C, Yano H, Ando Y, Usui T, Hotta Y, Miyazaki N, Tsujimoto A, Zaikokuji R, Matsumoto A, Kawaguchi T, Doi T, Yoshida T, Yoshida S, Kumada K, Ushikoshi H, Toyoda I, Ogura S

In Human- oder Tierstudien wurde keine systemische Toxizitt berichtet

It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 14,19,20