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All participants received a lifestyle intervention involving regular counselling regarding diet and physical activity

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Moreover, the resting heart rate variability (HRV) parameters also differed in ME/CFS patients, with a higher low frequency power of HRV (LFP) and a lower high frequency power of HRV (HFP)

Using a post hoc validation approach recommended by the Cochrane Collaboration [21], the correlation coefficient was found to be 0.64 for TIR in a crossover trial [12] and 0.70 for a before-after study [28]

7.3 Citrulline Citrulline is synthesized in enterocytes and serves as a functional marker of enterocyte mass and gut barrier integrity (Davila et al., 2013

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