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doi: 10.1111/bph.12888

Placebo), categories, and their interaction within anxiety (GAD-7)

The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance

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This approach balances therapeutic benefits against theoretical concerns about long-term continuous use, for which we lack human safety data