Genetic studies on the topic are actually pretty extensive, and several genetic variants have been identified that increase the risk of liver damage from chronic or high acetaminophen usage
This includes supplies for 500mg injections once a week
While there may be some promising preliminary findings overall, this research is still new and caution should be taken when concluding that taking oral supplements of GSH daily is necessary or beneficial
doi: 10.1016/j.mito.2013.01.008 15
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GSTP1 and GSTM1 do have multiple SNPs (for example, GSTP1 rs1695, A105G results in an amino acid substitution in codon 105 from valine to isoleucine associated with increased cancer risk), however, the null alleles described and focused on in this review result from gene deletion between the H3 and H5 regions flanking the gene [35]