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Semaglutide is a GLP-1 receptor agonist primarily used as a treatment for diabetes (Ozempic, Novo Nordisk) and more recently greenlit as a breakthrough treatment for obesity (Wegovy, Novo Nordisk)

Godfrey H, Leibovit-Reiben Z, Jedlowski P, et al

Senators repeatedly asked why Novo Nordisk, the maker of Ozempic and Wegovy, charges over $1,000 (746) in the US for the same drug it charges just $92 for in Germany

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Under physiological conditions, renal tubular epithelial cells highly express the carnitine transporter OCTN2 (SLC22A5), which mediates active reabsorption of filtered carnitine with an efficiency exceeding 95%

Several mechanisms may explain how GLP-1 therapy could theoretically influence bone health, though the clinical significance of these pathways remains under investigation