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2, moderate response
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It does not enter systemic circulation in measurable amounts, meaning serum levels remain undetectable and renal clearance is not a factor
For most drugs, this doesnt matter, but if you take medications where precise timing is important (such as some antibiotics that need an empty stomach, or thyroid hormone replacement), mention this to your prescriber or pharmacist
Funding This research was funded by Zhejiang Provincial Natural Science Foundation (LQ21H040008), Zhejiang Provincial Clinical Research Center for Pediatric Disease (2022E50003), Zhejiang Provincial Science and Technology Bureau Foundation (LGF22H040010), the Fundamental Scientific Research Project of Wenzhou (Y20210018), the Medical Health Science and Technology Project of Zhejiang Provincial (2022KY1207) and the Science and Technology Planning Project of Wenzhou (ZY2023032, ZY2021025)
Confirm with a serum B12 test (below 300 pg/mL warrants supplementation
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