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The bigger question is whether a once-daily version of the pill will be ready for a phase three trial in 2024, which is seen as the next big step toward potential Food and Drug Administration approval

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160 Moreover, overexpression of LMP-1 abolished TNF--mediated MMP-3 and MMP-13 expression by inhibiting p65 translocation, as well as MMP-3 and MMP-13 promoter activity

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