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The Future: Multi-Agonist Era Tirzepatide Dual agonist: GLP-1 + GIP Produces: Exceptional HbA1c reduction Major weight loss Retatrutide Triple agonist: GLP-1 + GIP + Glucagon receptor Early trials demonstrated unprecedented weight loss results approaching bariatric surgery outcomes

Energy balance - calories in versus calories out - still drives most changes in body fat

VDNP: Rate of respiration in the presence of an uncoupler (DNP), indicating maximal electron transport capacity

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None of the animals were sacrificed for this study

Common uses Skin rejuvenation Anti-aging Hair thinning Tesamorelin Growth Hormone Available GH-releasing peptide with a strong track record for visceral fat reduction and body composition when clinically appropriate