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Experimental studies and genome-wide association studies (GWAS) have identified a number of genes and their protein products that serve as UA transporters in the kidney: SLC22A12 [UA transporter (URAT1)], SLC2A9 (GLUT9), ABCG2 [ATP-binding cassette subfamily 2 also known as breast cancer resistance protein (BCRP)], SLC22A6 [organic anion transporter (OAT1)], SLC22A7 (OAT2), SLC22A8 (OAT3), SLC22A11 (OAT4), SLC22A13 (OAT10), SLC17A1 [Na + /phosphate transporter (NPT1)], SLC17A3 (NPT4), ABCC4 [multidrug resistance protein 4 (MRP4)] and PDZK1 (PZK domain containing 1 protein)

FIGURE 2 FIGURE 3 2.1 Hormones Lipedemas onset typically occurs during puberty, pregnancy, or menopause, suggesting that lipedema is a hormone-related disease and more likely an estrogen-related disease (Katzer et al., 2021)

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In the pre-marketing PIONEER-6 trial, a similar reduction in MACE rates was observed for oral semaglutide versus placebo, though statistical significance was not reached due to smaller event numbers than in SUSTAIN-6 [8]

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