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Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

At baseline, 95% of patients were treated with an ACE inhibitor or ARB, 16% were on sodium-glucose cotransporter 2 (SGLT2) inhibitors, 76% were on a statin, and 50% were on an antiplatelet agent

The preclinical literature supports this framing

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In another experiment with a similar model, exenatide injections into the spinal area decreased responses to heat and touch by increasing the spinal release of -endorphins, IL-10, and IL-4, associated with reduced pain perception [98,99]