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A 2025 systematic review and meta-analysis in Frontiers in Pharmacology (Mazur and colleagues, 16 studies, 6,098 participants) found that oral, sublingual, and intramuscular B12 all raised serum cobalamin to a comparable degree, with no statistically significant difference between routes

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PMID: 34829776 (view on PubMed) Medical disclaimer This article is for general education and is not a substitute for personalized medical advice, diagnosis, or treatment

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