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The first dose is the most likely to produce mild nausea, fatigue, and changes in bowel patterns

Ferroptotic cell death and tlr4/trif signaling initiate neutrophil recruitment after heart transplantation

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doi: 10.1002/cphy.c170014 67 LiuQYuZTianFZhaoJZhangHZhaiQet al

S2.4 Comparison between HH curves, pHp, and amount of niclosamide in solution To complete this theoretical assessment, plotted in Figure S5 (red symbols) is the pHp curve, giving the maximum amount of niclosamide expected to be in solution (uM) versus the solution pH (right axis) using the values derived from experiment of pKa = 6.87, S o = 1.77uM