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177,178 In conclusion, mitochondria activate NLRP3 inflammasome and initiate inflammatory response through diversified mechanisms including mtDNA leakage, ROS production, ATP, mitophagy and interaction with lysosomes

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The company's decision to advance both programs suggests confidence that the GLP-1/amylin dual pathway represents the future of obesity pharmacotherapy, with room for multiple formulations serving different patient preferences

doi: 10.1016/j.jneuroim.2019.577142