Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting
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Serious but rare side effects include pancreatitis (severe abdominal pain radiating to back), gallbladder problems (upper right abdominal pain, especially after eating), kidney issues (usually from severe dehydration), severe allergic reactions (difficulty breathing, severe rash, facial swelling), and vision changes (particularly in people with diabetes)
Erin Fox, associate chief pharmacy officer at University of Utah Health, whose team runs a drug information service that contributes to the society's list
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