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Most patients who forego invasive mechanical ventilation via tracheostomy die within 24 years from diagnosis, primarily from respiratory failure and complications of bulbar and diaphragmatic weakness [3]

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7.1.6 Enhancement of mucosal humoral immunity (IgA) Probiotics play a pivotal role in reinforcing the mucosal barrier by stimulating B-lymphocytes to differentiate into plasma cells

(PubMed) Ganz AB, Cohen VV, Swersky CC, et al