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The combination activates two separate points in the GH regulatory axis simultaneously, which is pharmacologically distinct from activating either point in isolation

The GLP in GLP-1 stands for glucagon-like peptide

Peripherally administered PYY(3-36) crosses the blood-brain barrier to act on Y2R-expressing NPY/AgRP neurons in the hypothalamic arcuate nucleus, inhibiting their activity and enhancing satiety signals (92)

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Many people confuse phentermine with GLP-1 medications, but they belong to entirely different drug categories that work through separate biological pathways

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