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HOW IT WORKS BOOK NOW Melanotan 2 works by activating melanocortin receptors, particularly MC1R, which stimulates melanin production in skin cells called melanocytes

PLoS ONE 2014;9:e102144

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Thus, peripheral endocrine signals, such leptin or GLP-1, can via activation of vagal afferents trigger central activation of PPG neurons in the NTS [351]