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In contrast, according to USP Medicine Supply Map data, the API market for higher-margin prescription opioid-combination formulations (e.g., acetaminophen/codeine) is almost entirely U.S.-based, as the figure below shows

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Studies demonstrate that Dihexa promotes dendritic spine formation, increases synaptic density, and enhances miniature excitatory postsynaptic currents (mEPSCs), indicating the formation of functional glutamatergic synapses

In America, meanwhile, tightening insurance policies are making it harder for patients to get the drugs, which are listed at up to $1,350 a month