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doi:10.1097/WCO.0000000000000391 Inadomi, K., Kumagai, H., Arita, S., Tsuruta, N., Takayoshi, K., Mishima, K.,
doi: 10.1007/s00296-016-3481-8 95 BinduSMazumderSBandyopadhyayU
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In conclusion, taken together these data (lack of tolerance development (tolerance studies), prolonged residual anticonvulsive activity, and postponed physical dependence/withdrawal hallmark in diazepam+bpc 157 chronically treated mice) with common benzodiazepines tolerance/withdrawal knowledge, it could be speculated that bpc 157 acts favoring the natural homeostasis of the gaba receptor complex as well as enhancing the gabaergic transmission, and having a mechanism at least partly different from those involved in diazepam tolerance/withdrawal, it may be likely used in further therapy of diazepam tolerance and withdrawal. And also reduces the hyperactivity that occurs when methamphetamine was administered to rats
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