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According to the applicant, the aprevo Cervical ACDF System device is different from C1831 because (1) the original (lumbar-specific) aprevo and the nominated aprevo Cervical ACDF System are separate and distinct products that have no overlap in anatomical indications for use or patient population

many reconstituted medications have limited stability and may need refrigeration or must be used within a short period to ensure potency and sterility

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"Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials." Arthroscopy

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