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Individuals under metformin treatment showed positive correlations were found with Bacteroids and Escherichia species and negative associations were obsevered with Ruminocococus and Faecalibacterium even with shorter duration of metformin treatment in Japanese cohort (Li et al., 2021)

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Coblyn JS and Brigham and Women's Hospital

Massaging can cause the medication to leak back out of the injection site and may increase bruising or irritation

These findings highlight the complexity of metformins effects, which may be age-, genotype-, and disease-context dependent, reinforcing the need for further experimental and clinical validation to clarify its therapeutic potential and risks in AD prevention across different populations