Telen, M
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It is a monophyletic genus comprising approximately 75 recognized species, with 40 to 60 of them being native to the Americas, representing close to 80% of its diversity (Costea and DeMason, 2001
Specifically, the pathologic effects of anti-GAD65Abs on GABA synthesis and release were specific to anti-GAD65Ab b78representing SPS- and CA-associated anti-GAD65Aband could not be reproduced by monoclonal anti-GAD65Ab b96.11, representing an epitope specificity associated with type 1 diabetes mellitus [80, 81, 82]
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Inactivation of DHODH in cancer cells with low GPX4 expression significantly increased intracellular lipid peroxidation, while in cancer cells with high GPX4 expression, DHODH inactivation synergized with inducers to enhance ferroptosis