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Among other metabolites that exhibited significant changes in the metabolomic analysis, spermidine (ratio: 1.3), a polyamine having strong anti-oxidant activity, acts as an intrinsic free radical scavenger

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Farnaud, S

Schulz J, Zimmermann J, Sorg C, Menegaux A, Brandl F

Cyclophosphamide, azathioprine, methotrexate, and mycophenolate inhibit lymphocyte proliferation and activation, thereby curtailing the immune response (110, 111)