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Exogenous ipamorelin competes for the same GHS-R1a receptors, so dosing during a period of high endogenous ghrelin (immediately before a meal, or during prolonged fasting beyond 1618 hours when ghrelin peaks) can actually reduce net receptor occupancy through competitive inhibition

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Overall, the 200 mg daily dose did not provide greater glycemic efficacy than the 100 mg daily dose