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On the other hand, iron overload induced ferroptosis in foam cells which led to plaque instability, and ferroptosis in foam cells increased IL-1 and IL-8 expression, promoting inflammatory responses (Su et al., 2021)

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Joint pain during tirzepatide treatment may result from rapid weight loss altering biomechanics and joint loading, increased physical activity unmasking pre-existing joint issues, or underlying conditions like osteoarthritis that are common in patients with obesity and type 2 diabetes

While it can be frustrating, it is usually a manageable hurdle on the path to better health

M.LiY.RamachandranS.McBrayerM