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For research applications requiring consistent dosing over extended periods, many laboratories adopt aliquoting strategies where bulk reconstituted solutions are divided into smaller single-use portions that can be frozen at negative twenty degrees Celsius or lower

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For example, Topamax at doses of 200mg daily or higher can reduce the effectiveness of combined hormonal contraceptives, and women of childbearing potential must use highly effective contraception as part of the Pregnancy Prevention Programme

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A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway