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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

Site rotation is essential for preventing cumulative tissue trauma and irritation

FEBS Lett1990 Mar 12;262(1):139-41

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Initially, GLP-1s were developed to treat type 2 diabetes and were marketed for that purpose under brand names such as Ozempic (semaglutide), Rybelsus (semaglutide), Victoza (liraglutide), and Mounjaro (tirzepatide)

doi: 10.3390/ijms25179302 167 Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC)