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If GLP-1-GIP-Lani ever reaches the clinic, the relevant variants are likely to include rs10305420 in GLP1R (-0.76 kg additional weight loss per allele on GLP-1 monotherapy, per the 23andMe Nature paper from April 8, 2026), variants in GIPR tied to nausea and tolerability, and possibly variants in PPARG and PPARD that affect nuclear receptor signaling

Taking care when lifting objects, bending at the knees instead of the waist, and avoiding jerky movements may help protect the back

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Although no subgroup analysis was performed specifically for older adults, changes at the end of 24 weeks were reported to be independent of age [58]