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The tissue and cell disruption during processing (e.g., mixing, cutting, crushing, freezing/thawing, and high pressure treatment) makes native polyglutamyl folates accessible for endogenous conjugases (-glutamyl hydrolases) and results in the hydrolysis to monoglutamyl folates in vegetables (e.g., leeks, cauliflower, broccoli, spinach, soybeans, green beans, cowpea leaves, turnip, and carrot) and fruits (e.g., orange, papaya, sweet cherry, strawberry, and blackberry)

IGF-1 LR3 activates the IGF-1 receptor, triggering PI3K/Akt (cell survival, mTOR, protein synthesis) and Ras/MAPK/ERK (proliferation, differentiation) cascades

Cohort study of adult patients with haemoglobin SC disease: clinical characteristics and predictors of mortality