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An exclusion is severe alcoholic hepatitis, as this is likely accompanied with a history of prolonged alcohol abuse, resulting in chronicity of the liver injury

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Women using oral contraceptives should use a non-oral method or add a backup method for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase

A loss of firmness and elasticity: Damage to collagen, elastin, and other supportive proteins, contributing to wrinkles and sagging

Glutathione, a potent endogenous antioxidant compound, is a likely mediator of these effects