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BPC-157 , a synthetic peptide derived from a protective protein found in gastric juice, has been widely explored in laboratory settings for its potential influence on angiogenesis, cytoprotection, and tissue repair mechanisms
Tranexamic acid (TXA), a lysine analogue and antifibrinolytic agent, inhibits the binding of plasminogen originating from endothelial cells to keratinocytes resulting in the diminution of melanocyte activators production (e.g., arachidonic acid, prostaglandins, leukotrienes, -MSH) [6, 27, 90]
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The annulus fibrosus and cartilaginous endplate suffer delamination, tears, fractures and clefts of their respective extracellular matrix at both microscopic and macroscopic scales