In practice contexts, tolerance is generally reported as good when product quality is reliable
10.1186/1476-5918-8-1 101 FjellA
The 2025 Frontiers in Aging clinical review (Frontiers in Aging 2025) summarises the documented short-term adverse effects in adult populations: peripheral oedema and fluid retention are common at initiation, carpal tunnel syndrome occurs in a meaningful proportion of users, hyperglycaemia and insulin resistance can emerge because GH is physiologically counter-regulatory to insulin, and gynaecomastia has been reported, particularly at higher doses
CagriSema reduces blood pressure in adults with overweight or obesity: REDEFINE 1
Local Reactions: Redness, swelling, itching, or pain at the subcutaneous injection site
You can learn more about this approach in Why Bioavailability Matters