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Most standard functions, including detoxification of undesirable substances and cellular protection against oxidative damage, are carried out with the help of glutathione

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Conjugated metabolites often have higher clearance than the parent drug, due in part to active excretion into urine and/or bile

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Mice heterozygous for mitochondrial trifunctional protein have compromised mitochondrial -oxidation and develop hepatic steatosis alongside a compensatory upregulation of CYP2E1-facilitated FAO and oxidative stress [101, 102]