Understanding why this occurs and when it requires medical attention helps patients manage this common experience while continuing effective therapy
Several papers point to a preservation or increase in lean body mass.21 One even showed improvements in muscle composition (a decrease in muscle fat) in non-diabetic participants.27 Others have seen a reduction of lean body mass, making up around 20-50% of total weight lost, but its important to note that this was a review of research into several anti-diabetic drugs including some that arent GLP-1 RAs.26 Research into low-calorie diets reveals that exercise and a high protein intake can help preserve muscle mass and even build muscle while restricting calories, so you cant just eat junk, not exercise, and still expect these drugs to work miracles.22 Your overall health can improve by adding exercise and a healthy, protein-rich diet to a GLP-1 RA routine
Hematoxylin and eosin staining and immunohistochemistry Tissues were fixed in 10% neutralbuffered formalin and then embedded in paraffin
doi: 10.1177/25424823251388650
References Vora, RitaV, et al
a final selection of 9 scientific papers was made based on their study type and the specific peptide examined
