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When analysing trials with different durations separately, a statistically significant difference across groups was detected ( p = 0.01, Figure 2): a significant positive association of GLP1RA with the incidence of cancer was found in the trials lasting 52 weeks (MHOR 2.20, 95% CI [1.32, 3.64], p = 0.003, Figure 2), whereas the difference was not significant for trials with a duration between 53 and 103 weeks (MHOR 1.17, 95% CI [0.87, 1.56], Figure 2), and no difference was found between groups for trials lasting at least 104 weeks (MHOR 1.02, 95% CI [0.95, 1.10], Figure 2)

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At the same time, the relationship appears highly complex and influenced by overall diet, gut microbiome composition, metabolic health, and lifestyle

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Retatrutide has a half-life of approximately 6 days, which supports the once-weekly dosing frequency