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135,136 Further investigations are warranted to elucidate the mechanisms underlying GLP-1RAs action in PD

Do Not Use Semaglutide If You: Have a personal or family history of medullary thyroid carcinoma (MTC) Have Multiple Endocrine Neoplasia syndrome type 2 (MEN-2) Are pregnant, planning to become pregnant, or breastfeeding Have a history of pancreatitis or unexplained, persistent abdominal pain Have severe gastrointestinal disease (including gastroparesis) Have had an allergic reaction to semaglutide or any of its components Use With Caution If You Have: Gallbladder disease or a history of gallstones Kidney or liver impairment Diabetic retinopathy High triglyceride levels Frequent gastrointestinal issues such as reflux, nausea, or vomiting A history of alcohol use disorder Possible Side Effects May Include: Mild to moderate nausea, vomiting, diarrhea, or constipation Bloating or decreased appetite Fatigue or dizziness In rare cases, pancreatitis (inflammation of the pancreas) symptoms may include severe, persistent abdominal pain radiating to the back, sometimes with nausea or vomiting

Additionally, interacting proteins (readers) of P-SF3B1 and their functions in the activated and catalytically active spliceosomes (B* C) also remain elusive

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Plump AS, Scott CJ, Breslow JL

Some even split doses into tiny injections multiple times per week