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After 72 weeks of treatment: 5 mg dose: 15.0% mean body weight reduction 10 mg dose: 19.5% mean body weight reduction 15 mg dose: 20.9% mean body weight reduction Placebo: 3.1% mean body weight reduction Among participants receiving 15 mg, approximately 57% achieved at least 20% weight loss

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Current data emphasizes receptor selectivity, intracellular pathways, and broader systemic observations, but no definitive applications have been established

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